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KMID : 0351619700110020335
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Kyungpook Medical Journal
1970 Volume.11 No. 2 p.335 ~ p.348
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Effects of Promethazine upon Hepatic Injury Hroduced by Carbon Tetrachloride in Rats
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Abstract
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The experiment was carried out to clarify the intriguing "protective" effects of promethazine on ultrastructural alterations in the hepatic cells exposed to carbon tetrachloride.
The carbon tetrachloride and promethazine hydrochloride were administered into the albino rats, either singly or combined. carbon tetrachloride was given subcutaneously with a dose of 0.5㎖ per kg of body weight and promethazine was injected intraperitoneally with a dose of 25.0mg for kg of body weight.
Hepatic lesions were examined histopathologically by the measure of both lgith and electron microscopes with the following conclusions.
1. Light-microscopically, hepatic tissue of animals receiving carbon tetrachloride alone revealed marked degenerative changes and frank necrosis in the central zone of lobules, while the hepatic tissue of animals which received both carbon tetrachloride and promethazine revealed only minimal changes. Hepatic tissue of the animals fed only with basal diet or of those which received promethazine alone revealed no significant pathologic changes.
2. Electron-microscopically, hepatic cells affected by carbon tetrachloride revealed a wide range of ultrastructural changes. The nucleus appears to be considerably active, and rough surfaced endoplasmic reticulum revealed variable changes evidenced by swelling of this organel and shedding of ribosomes. The mitochondria later underwent swelling with loss of cristae. Animals which received both promethazine and carbon tetrachloride revealed relatively milder changes than in those which were treated only with carbon tetrachloride, and almost completely recovered within twentyfour hours. The animals which received promethazine alone revealed no significant ultrastructural changes in their hepatic cells.
3. promethazine, therefore, was thought to have significant protective effects upon hepatic injury produced by carbon tetrachloride.
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